Improved Lymphocyte Function-associated Antigen-1 (LFA-1) Inhibition by Statin Derivatives
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منابع مشابه
Signaling by lymphocyte function-associated antigen 1 (LFA-1) in B cells: enhanced antigen presentation after stimulation through LFA-1
To examine the role of lymphocyte function-associated antigen 1 (LFA-1) expression on murine B cells as it pertains to their function in T cell activation, we carried out antigen-presentation assays in tissue culture wells coated with a purified, secreted form of the murine intercellular adhesion molecule 1 (ICAM-1). We observed a significant decrease in the concentration of antigen required to...
متن کاملSignaling by Lymphocyte Function-associated Antigen 1 (LFA-1) in B Cells: Enhanced Antigen Presentation after Stimulation through LFA-1 By
To examine the role of lymphocyte function-associated antigen 1 (LFA-1) expression on murine B cells as it pertains to their function in T call activation, we carried out antigen-presentation assays in tissue culture wells coated with a purified, secreted form of the murine intercellular adhesion molecule 1 (ICAM-1). We observed a significant decrease in the concentration of antigen required to...
متن کاملShedding of lymphocyte function-associated antigen-1 (LFA-1) in a human inflammatory response.
Shedding of adhesion molecules has been described for members of the selectin and immunoglobulin superfamilies, but integrins are not known to be shed. Here, we describe shedding of the integrin lymphocyte function-associated antigen-1 (LFA-1; CD11a/CD18) from human leukocytes during the cutaneous inflammatory response to the blistering agent cantharidin. Expression of LFA-1 was significantly d...
متن کاملLymphocyte Migration in Lymphocyte Function-associated Antigen (LFA)-1–deficient Mice
Using lymphocyte function-associated antigen (LFA)-1(-/-) mice, we have examined the role of LFA-1 and other integrins in the recirculation of lymphocytes. LFA-1 has a key role in migration to peripheral lymph nodes (pLNs), and influences migration into other LNs. Second, the alpha4 integrins, alpha4beta7 and alpha4beta1, have a hitherto unrecognized ability to compensate for the lack of LFA-1 ...
متن کاملShedding of Lymphocyte Function-associated Antigen (LFA)-1 in a Human Inflammatory Response
word count: 196, Total text: < 5000. Corresponding author: Professor Dorian O. Haskard, BHF Cardiovascular Medicine Unit, Faculty of Medicine, Imperial College London, Hammersmith Hospital, Du Cane Road, London W12 0NN, U.K. Tel: +44 (0)20 83833064 Fax: +44 (0)20 83833064 [email protected] Blood First Edition Paper, prepublished online January 17, 2006; DOI 10.1182/blood-2005-09-3695 Cop...
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ژورنال
عنوان ژورنال: Journal of Biological Chemistry
سال: 2004
ISSN: 0021-9258
DOI: 10.1074/jbc.m407951200